Conduct specialized, innovative drug delivery research to address specific delivery problems for peptide/biologic and nucleic acid pipeline assets.
Conduct research on innovative drug delivery formulation technologies for macromolecule drugs to extend their release, stabilize and sustain their pharmacokinetics (PK), or alter PK to improve overall compliance.
Explore lipid/polymer based particulate systems and gel based systems to apply to pipeline drugs.
Formulate prototypes for each delivery approach, characterize the material, test the in vitro drug release experiments, and collaborate to test the in vivo PK
Contribute to the experimental design, plan and coordinate in vitro/in vivo experiments, perform chromatographic / spectroscopic analysis, analyze the data and present findings.
Work collaboratively with team members to execute studies
PhD in pharmaceutical sciences, drug delivery, biotechnology or related field with 0-2 years of experience.
Fundamental knowledge of drug delivery (large molecules - peptide, proteins, etc.) systems through thesis project.
Hands-on expertise with drug delivery technology design, formulation prototyping, use of appropriate formulation processing unit operations, in vitro drug release testing, and material characterization is required.
Characterizing in vivo testing
Peptide and nucleic acid experience required
Lipids and polymers experience preferred
Knowledge of pharmacokinetics
Strong proficiency in interpreting experimental data and good familiarity with routine analytical techniques (HPLC/UPLC chromatography, UV/fluorescence spectrometry).
Collaborate to gain a broad mechanistic view of delivery performance.
Highly motivated, exhibit an innovative mindset, and possess strong verbal, written, and interpersonal communication skills to effectively function as an individual contributor in a team environment.