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Assistant/Associate Scientist

Job Post Index 214CDE-Sy##
Location Devens, MA
Description: Description
  • Participate in the development and optimization of downstream processes for the production of biologics at different clinical stages, as well as assist in the development of a next generation downstream manufacturing platform.
  • PD scientists and engineers contribute to cross-functional teams to meet highly visible business objectives.
  • Design and execute protocols to solve process-related manufacturing investigations and drive process improvements by using laboratory and pilot scale-down models in protein chromatography, viral inactivation, viral filtration, ultrafiltration/diafiltration, membrane filtration, depth filtration, and centrifugation.
  • Document experimental data and results, verify and interpret data with respect to the laboratory protocol and manufacturing process.
  • Evaluation of new process technologies, including multicolumn continuous chromatography (MCC) operation.
  • Characterization of products and impurities.
  • Buffer preparation and column packing.
  • Appropriate GLP/GMP procedures must be followed.
Skills: Qualifications
  • MS or BS in Biochemistry, Chemical Engineering, or related field with 2–4 or 4–6 years, respectively, of relevant industrial and/or academic experience.
  • Knowledge of protein purification, protein stability, and demonstrated experimental skills for laboratory work are required.
  • Experience with AKTA purification operations and UNICORN method writing is helpful.
  • Experience with process scale-up/scale-down and process characterization is a plus.
  • Critical qualities include a high degree of initiative, good verbal and written communication skills, strong scientific skills and attention to detail, and the ability to work in a team environment.
  • Experience using Affinity chromatography, CEX, AEX, and HIC is highly desirable
  • Membrane filtration experience is a plus.
  • Knowledge in process development is a plus.

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