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Postdoctoral Fellow

Job Post Index 23DF1E-Sy##
Location Lexington, MA
Description: Description
  • Develop and establish mass spectrometry-based proteomics approaches to analyze cell samples to support the development of cell therapy programs.
  • Work closely with cell therapy group to characterize cell therapy products and impact clinical programs.
  • Interact with cross-functional teams of biologists, bioanalytical scientists and computational scientists.
  • Author SOPs, technical reports and manuscripts, as well as present work both internally and externally.
  • Evaluate and implement new technology platforms to build scientific capabilities in cell therapy characterization.
  • Establish, optimize and maintain the membrane protein characterization workflow using the available resources and apply the workflow to different cell therapy products.
  • Design and execute proteomics experiments from sample preparation, LC-MS/MS operation to data analysis and interpretation.
  • Keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained.
  • Review study results and write proteomics report and other documents
  • Present project updates to the group, department and project teams.
  • Prepare oral or poster presentation in scientific conference and publish study approaches/applications in scientific journal if possible.
  • Evaluate and bring in new technology platform.
  • Take responsibility in instrument/system routine maintenance and troubleshooting of Q Exactive Plus mass spectrometer as well as nano-UPLC systems.
Skills: Qualifications
  • Ph.D. in biochemistry, analytical chemistry or related area with relevant research experience is required.
  • Excellent knowledge and hands-on experience in biological sample preparation and LC/MS based proteomics.
  • Comprehensive understanding of protein biochemistry and molecular biology is highly desired.
  • Extensive experience in protein isolation and purification from cells and other biological samples.
  • High level of proficiency in quantitative proteomics techniques (e.g. label free, iTRAQ/TMT, SILAC) and peptide fragmentation methods.
  • Solid background and broad hands-on experiences with at least one of the Thermo Orbitrap mass spectrometers: Q Exactive, Plus, HF, HF-X or more advanced models.
  • Direct experience with UHPLC/nano-HPLC instrumentation is a must.
  • Proficiency in software tools such as Xcalibur, MaxQuant, Mascot, Proteome Discoverer, Biopharma Finder and Skyline.
  • Experience with downstream data analytics (multi-dimensional data mining, high dimensional data analysis) is a big bonus.
  • Excellent analytical, organizational and communication skills.
  • Ability to conduct multiple laboratory and project tasks efficiently.
  • Ability to work in a team-oriented environment.
  • General lab competencies such as equipment maintenance and compliance activities.
  • HPLC-MS + mass spectrometry + protemics data analytics experience

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